In Silico Study of the Ontogenetic Changes in Action Potential Properties of Mouse Cardiac Pacemaker Cells

摘要

Heart rhythm of mammals changes during ontogenesis and postnatally. A study of electrophysiological properties of sinoatrial node during ontogenesis makes it possible to clarify cellular mechanisms of heart rhythm changes during cell development. Here we introduce novel results of the experimental study of action potential changes during ontogenesis. We present detailed information about changes of action potential phases during ontogenesis and postnatal development. An important area of the study of ionic mechanisms of action potential generation is a development of mathematical models of sinoatrial node cell and defining the ranges of model parameters which corresponds to different stages of ontogenesis. This paper outlines methods of model parameters variation for fitting action potential signals to the experimental data.