Single Nucleotide Polymorphism (SNP) Data Analysis by using Bootstrap Method

摘要

In this paper it is described how to analyze SNPs data by using bootstrap method. The bootstrap method is used in case of the chi-square Q~2 statistics and the likelihood ratio statistics G~2. It is described how to use the method in case-control association studies. Simulation study is used to explore the properties of the method. Based on the original table, it can be construct a new table and related statistical value of statistics. Figure 1(a) and Figure 1(b) presents the number B = 1.000.000 statistical value of chi-square test and likelihood ratio test, respectively. The bootstrap p-values for two (original) statistical tests are 1.2 × 10~(-5) and 1.9 ×10~(-5), respectively. The described method can also be applied to the whole genome case-control association studies which uses thousands SNPs.