Immobilization of Chiral Secondary Amine Catalysts and ItsApplication in Continuous-Flow Reactions

摘要

Small organic molecules catalyzed carbon-carbon (C-C) bond construction hasemerged as one of the most powerful methods to prepare the basic skeleton ofmolecules.Among those,proline-derived organocatalysts occupy a certain placeemploying enamine or iminium activation modes.Despite the potential of traditionalorganocatalysts for enantioselective homogeneous processes,the sustainability stillsuffers some limitations,such as short catalyst life time,catalyst reuse and recycleproblems,complicated purification operation,and scant productivity.Therefore,thedevelopment of supported catalysts with high reactivity and recycle ability is stillhighly in demanding.