Protein photodamaging effect of P(V)tetrakis(4-chlorophenyl)-porphyrin derivatives

摘要

Photodynamic therapy (PDT) is a less invasive cancer treatment,and porphyrinderivatives are the important photosensitizers for PDT.Biomolecule oxidation through reactiveoxygen formation is the important mechanism of PDT by porphyrins,however,hypoxiccondition of tumors suppresses the PDT effect.To solve this problem,we have studied theporphyrin P(V) complexes,which are considered to have a therapeutic effect through electrontransfer oxidation under hypoxic condition.