Highly Efficient Synthesis of 1,4-Dihydropyridine DerivativesUsing DBU

摘要

The 1,4-dihydropyridine family is a significant class of pharmacophore compoundsfrequently found in the field of drug such as hypertension and angina treatment.In addition,it is known that these compounds exhibit various activities such as antioxidative,antidiabetic,and antitumor.1 To date,numerous synthetic methods for 1,4-dihydropyridinederivatives have been reported due to such a significant biological importance.For example,Yan's group reported unsymmetric polysubstituted dihydropyridines were synthesized by afour-components reaction of aromatic aldehydes,malononitrile,arylamines,andacetylenedicarboxylate in the presence of triethylamine as a base promoter at roomtemperature.2 However,in the synthesis of the skeleton with β-enaminoimides as asubstrate,heating conditions using piperidine as a base were required.3