Synthesis of Azaheterocyclic Derivatives of 5,7-Dimethoxycoumarins by CH/CH Functionalization with Quinazolines

摘要

A new approach was developed for nucleophilic substitution of hydrogen in quinazoline derivatives under the action of 5,7-dimethoxycoumarins. Such reactions provide direct synthetic route avoiding pre-functionalization of the C-H bond. The advantages of this environmentally benign approach are high regio- and chemoselectivity, and an easy workup procedure.