Light-Driven DNA Amplification based on Toeholdless Strand Displacement Reaction assisted by A Cationic Polymer

摘要

Recent decades of years, DNA has drawn much attention for its possibility as an outstanding engineering molecule in nanotechnology. By programming sequence of DNA, precise control of DNA binding behavior is accessible. Considering employing light, a green and constant resource in nature, as tools to manipulate DNA conveniently, our group has established a facile protocol that achieves reversible photo-regulation of DNA binding behavior by incorporating photo-responsive azobenzene moieties into DNA strand. There have been several photo-controllable DNA nanodevices developed based on this protocol, such as a photo-responsive DNA tweezer or a photo-regulated DNAzyme.