Structure and Oxygen Binding Affinity of Hemoglobin-Albumin Cluster as an Artificial Oxygen Carrier

摘要

Since the 1980s, hemoglobin (Hb)-based O2-carriers of several types have been prepared and clinically evaluated.1 Nevertheless, side-effect (increased blood pressure) and low efficacy have prevented their practical applications. Recently, we have synthesized a covalent core-shell structured protein cluster composed of Hb and human serum albumin using a bifunctional cross-linker (BMPS, Fig. 1A), Hb-HSA3, as a unique artificial O2 carrier.2