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HEMOGLOBIN-ALBUMIN COMPLEX, AND ARTIFICIAL PLASMA EXPANDER AND ARTIFICIAL OXYGEN CARRIER, EACH CONTAINING SAME

机译：血红蛋白-白蛋白复合物，人造血浆膨胀剂和人造氧气载体，每个包含相同

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摘要
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摘要

A novel hemoglobin-albumin complex which has high stability of the oxygenated form, has high biocompatibility, and is easily prepared (synthesized), and an artificial plasma expander and an artificial oxygen carrier containing the complex are provided. The hemoglobin-albumin complex of the invention is characterized by having hemoglobin as the core, and albumin as the shell bound via a crosslinker to the above hemoglobin. Also, the artificial oxygen carrier of the invention is characterized by containing the hemoglobin-albumin complex of the invention.

机译：提供了一种具有氧合形式的高稳定性，具有高生物相容性并且易于制备（合成）的新型血红蛋白-白蛋白复合物，并且提供了一种包含该复合物的人工血浆膨胀剂和人工氧载体。本发明的血红蛋白-白蛋白复合物的特征在于，以血红蛋白为核，以白蛋白为壳，通过交联剂与上述血红蛋白结合。另外，本发明的人造氧载体的特征在于含有本发明的血红蛋白-白蛋白复合物。

著录项

公开/公告号EP2682407B1

专利类型
公开/公告日2016-09-14

原文格式PDF
申请/专利权人 CHUO UNIVERSITY;
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申请/专利号EP20120752415
发明设计人 KOMATSU TERUYUKI;TOMITA DAIKI;
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申请日2012-02-20
分类号C07K19;A61K38/16;A61P7;A61P7/06;C07K14/76;C07K14/805;C07K14/765;A61K38;
国家 EP
入库时间 2022-08-21 14:52:54