Synthesis of p-Methoxyphenyl Sulfated GalN3 Derivatives and Their Inhibition of Japanese Encephalitis Virus Infection

摘要

It is known that Japanese Encephalitis Virus (JEV) infection begins when the envelope protein on the lipid membrane wrapping the virus binds to the receptor molecule on the host cell membrane and is taken into the cell.1, 2 We thought that actuating compounds having a similarity to structure of sulfated glycosaminoglycan such as chondroitin sulfate E and heparin which are reported as receptor molecule that inhibit JEV infection could inhibit the virus from entering the cell, therefore we synthesized p-methoxyphenyl β-GalNAc4S and β-GalNAc4S6S derivatives and reported that they inhibit JEV infection.3