Aggregate formation and lipid-related activity of 5aTHQs, cryptic actinomycete metabolites

摘要

Membrane lipids are the major structural components of the cell membrane. Lipids show numerous physical interactions with membrane proteins to orchestrate biological events, such as signal transduction and cell polarity processes, while they are involved in dynamic metabolism to maintain cell homeostasis and adapt the environment. However, roles played by lipids in cells and bodies are poorly understood because of their huge level of chemical diversity and the lack of suitable analytical tools.