A Novel Biphasic Scaffold with Gradient Pore Structures for Osteochondral Tissue Engineering

摘要

This study was aimed at using biomimetic strategies to construct a biphasic scaffold. Biphasic scaffolds were constructed using the 3-dimentional printing technology with two phases: the bony phase and the chondral phase. The bony phase was using the composition of Poly(lactide-co-glycolide) (PLGA) and Polyethylene glycol PEG; the chondral phase was using hydrogel consisting of GelMA and hyaluronic acid. Also we designed a gradient pore size in the bony phase to better mimic the natural bone tissue. In vitro tests have shown the stratified scaffolds with gradient designs were effective for the multi-tissue formation.