Effectiveness of laser accelerated ultra high dose rate protons in DNA DSB damage induction under hypoxic conditions

摘要

Particle therapy has been regarded as an effective modality for treating tumors due to higher RBE than photons and precise dose delivery to the deep seated tumors near the critical organs offering significantly sparing of the normal tissues~1. High LET ions have been reported to kill radioresistant and hypoxic tumor cells~(2,3). The large footprint, installation and operational costs of the current particle therapy facilities pose a challenge towards the widespread accessibility of particle therapy. High-power lasers have successfully demonstrated the generation of ion beams~(4-6), which have been proposed as a route towards reducing the overall footprint and costs of future hadrontherapy facilities~7.