Effects of Pre-inhalation of Salbutamol on Cough Reflex Induced by Sufentanil

摘要

Purposes: This study was designed to evaluate the effect of pre-inhalation of salbutamol aerosol (200μg) and injection speed on sufentanil-induced cough. Methods: 160 patients aged 25-62yr, ASA I - II, scheduled for various elective surgical procedures under general anesthesia were randomly allocated into four groups of 40 each. Group II, IV served as control received saline aerosol, and Group I, III received a pre-inhalation of one metered aerosol puff of salbutamol (200μg) 10min prior to intravenous injection of sufentanil. Sufentanil 0.5μg/kg was administered within 3s in Group I, II, or over 30s in Group III, IV. The concentration of sufentanil was 10μg/ml. The incidences and severity of cough that occurred within 1 min after the injection of sufentanil were recorded, the HR and SBP at pre-anesthetic (T1), 5 minutes after inhalation (T2), and 1 minute after injecting sufentanil (T3) were also recorded. Results: The incidence of cough in Group I, IV (10%,12.5%) were less than Group 11 (37.5%) (p<0.05); The incidence of cough in Group III (2.5%) was significantly lower Group II (p<0.01). The highest non-invasive blood (NIBP) and heart rate (HR) were at T3 timepoint in Group II (p<0.05). Conclusions: The pre-inhalation of salbutamol (200μg) combined with a prolonged injection time significantly reduced the incidence of sufentanil-induced.