Synthesis of Nanoparticle-Hydrogel Composites Based on Crosslinked by Al Ions Poly(Sodium Acrylate), Fe_2O_3 and y-AlOOH

摘要

In the present study, novel nanoparticle-hydrogel composites have been synthesized as a potential hemostatic wound-healing agent. Poly(sodium acrylate) has been cross-linked by aluminum ions, forming physical hydrogel, which was used as a matrix, while nanoscale boehmite (y-AlOOH) and Fe_2O_3 were used as fillers. A new approach to hydrogel synthesis has been proposed. This technique involves oxidation of aluminum nanoparticles suspended in poly(sodium acrylate) concentrated solution, thus, generating aluminum ions, which serve as a cross-linking agent, forming hydrogel network. In order to obtain nanoparticle-hydrogel composites, nanoscale fillers were added to polymer solution prior to hydrogel formation. MTT-assay, performed for analyzing the cytotoxic effects of all synthesized nanocomposites, revealed its non-toxicity at the concentrations 0.1-0.00625 mg/ml.