Antibiotic Concentrations in the Airways Of Cattle

摘要

Antimicrobial concentration at the site of infection is a critical piece of information to predict clinical efficacy. In respiratory disease of cattle, the initial site of infection is the airways of the lower respiratory tract as bacterial pathogensmove from the upper airways with the assistance of superimposed viral infections and the stress of transport and comingling. Therefore sampling the bronchi and bronchioles has become the gold standard. Furthermore, once respiratory disease is established, bacterial pathogens may invade across the epithelium and interstitial fluid moves into the airways across the damaged epithelium. This suggests that measuring drug concentrations in the interstitial fluid of the lungs may also be useful in understanding the efficacy of antimicrobial therapies. As discussed in the previous presentation, the approach to sampling the airways and interstitial fluid to measure drug concentration can influence the results that are obtained. Nonetheless, multiple studies have been performed to attempt to determine the drug concentrations at these sites.