antibiotic concentrations dihydroric 890 a9, method for preparation thereof and pharmaceutical preparations containing this antibiotic.

摘要

The cpd. desacetyl-dihydro-890A9 of formula (I) and its salts are new. In the prepn. of (I), the cpd. dihydro-890A9 (II) is treated with an enzyme capable of hydrolysing the N-acetyl group, pref. N-acetyl-dihydro-890A9-amidohydrolase. In the prodn. of microorganisms with N-acetyl-dihydro-890A9-amidohydrolase, microorganisms are selected which can utilise N-acetyl-ethanolamine for growth, and the selected microorganisms are tested for the presence of N-acetyl-dihydro-890A9-amidohydrolase. (I) is man antibacterial active against Gram-positive and Gram-negative bacteria, and is use of human and veterinary medicine for the treatment of bacterial infections. It can also be used as an animal feed additive, as a preservative for feeds and foods, as a disinfectant and as an industrial bactericide.