Objective To investigative the effect of time-dependent antibiotics and concentration-dependent antibiotics in the prevention of surgical infection during cardiopulmonary bypass (CPB) operations. Methods Retrospective study was carried out in 264 cases of prophylactic use of antibiotics in the cardiac CPB surgery. These patients were divided into two groups. There werel24 cases in group A, which received time-dependent antibiotics 24 hours before operation; And there were 140 cases of group B, which received prophylaxis concentration-dependent antibiotics 24hours before operation. Postoperative infections were analyzed, including infections of respiratory tract, urinary tract, wound, mediastinum and infective endocarditis. Results There were 13 cases ( 10. 5 % ) of postoperative infection in group A, which was significantly lower than 27 cases (19.3%) of postoperative infection in group B (P<0. 05). Conclusion The time-dependent antibiotics are more suitable than the concentration-dependent antibiotics for preventing the CPB infection.%目的 研究体外循环(extracorporeal circulation,CPB)心脏手术中,时间依赖性抗生素及浓度依赖性抗生素预防手术感染的效果. 方法 回顾性研究264例CPB心脏手术中抗生素的预防性应用,将病人分为两组,A组124例,病人术前24h内预防性使用时间依赖性抗生素；B组140例,病人术前24h内预防性使用浓度依赖性抗生素.统计术后感染情况,包括呼吸系统、泌尿系统、切口和纵隔感染以及感染性心内膜炎等分项. 结果 A组术后感染13例(10.5％),B例27例(19.3％),有显著性差异(P＜0.05). 结论 时间依赖性抗生素比浓度依赖性抗生素更适合用于预防CPB心脏手术感染.
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