EFFECT OF HYDROCORTISONE ADMINISTRATION ON LEPTIN AND ADIPONECTIN SYNTHESIS IN HEALTHY DOGS

摘要

The objective of the present study was to examine whether circulating concentrations of leptin and adiponectin, distribution of abdominal fat, and mRNA expressions of leptin and adiponectin in abdominal adipose tissue were affected by hydrocortisone administration. Six laboratory dogs each received hydrocortisone (8.5 mg/kg) orally every 12 hours for 90 days. We measured the serum concentrations of leptin and adiponectin using canine-specific ELISA kits. We quantified visceral fat using CT scanning,and we analyzed the mRNA expressions of leptin and adiponectin in abdominal fat using real-time PCR.