EVIDENCE FOR GENETIC PREDISPOSITON TO BORRELIA BURGDORFERI INFECTION IN PURPOSE BRED BEAGLES

摘要

Borrelia burgdorferi (BB) and Anaplasma phagocytophilum (AP) are transmitted by Ixodes spp., and seroprevalence rates in endemic areas can be greater than 15% in dogs. A genetic predisposition to infection (Bernese mountain dogs) or clinical illness associated with BB has been suggested, particularly in people and dogs with Lyme nephritis (Retriever breeds). In vaccine studies, wild caught /. scapularis adults placed in feeding chambers and allowed to feed for seven days usually results in at least a75% BB infection rate. Recently, an /. scapularis infestation study using a previously reported model and ticks with a similar BB carriage rate from the same collection area previously used, resulted in only a 29.2% infection rate. The purpose of this report is to describe the genetic relatedness of the dogs used in that study.