Time-resolved circular dichroism: what can we learn on conformational changes?

摘要

Time-resolved circular dichroism (CD) measurements can yield relevant information on the dynamics of conformational changes in molecules on the condition that some a priori knowledge is obtained. This can be the use of simple models such as the excitonic coupling or the octant rule or the phenomenological relationship between far-UV CD and secondary structures in proteins for example. This article describes such experiments where CD has brought relevant conformational information.