Determination of competitive adsorption isotherm of the etodolac enantiomers using inverse method

摘要

The competitive adsorption isotherm of etodolac enantiomers on a cellulose carbamates-based chiral stationary phase (Chiralcel OD) at 25°C was determined in this study by the inverse method (IM). An equilibrium dispersive (ED) model combined with bi-Langmuir adsorption model was used in predicting the elution profiles. The adsorption isotherm model with 5 parameters was determined by fitting the two overloaded band profiles. The non-dominated sorting genetic algorithm (NSGA-II) and Levenberg-Marquardt algorithm (LMA) were crucial tools and utilities in this process. Suitable model parameters have been obtained and the experimental results were in good agreement with the model predictions.