The Polysaccharide from the Seaweed Sargassum Graminifolium and its Effect on Calcium Oxalate Crystallization based on Determination of Electrical Conductivity

摘要

The effect of sulfate polysaccharide (SGP) isolated from the seaweed Sargassum graminifolium on the growth of urinary crystal calcium oxalate (CaOx) was investigated by means of Electrical conductivity. The results showed that adding solution of SGP can inhibit on CaOx crystallization under the same temperature and pH of supersaturated solution. Moreover, increasing concentrations of SGP resulted in increased inhibiting effect on CaOx crystallization. Compared with control conditions, both SGP and trisodium citrate significantly inhibited CaOx crystallization. As we all known, trisodium citrate is used for treating and preventing urine stone. SGP contained carboxyl and hydroxyl and sulfuric acid medium through the analysis of infrared spectrum, which provided that chemical foundation for the inhibition of CaOx. These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization properties.