Anisotropic Supported Lipid Bilayers for Spatially Dynamic Surface Protein Presentation

摘要

Through the combination of the thin film stretching method for ellipsoidal microparticle generation and the liposome fusion method for supported lipid bilayer synthesis, a robust procedure for the development of ellipsoidal SLBs has been developed. Anisotropic SLBs were successfully synthesized and demonstrated to be capable of binding to multiple biotinylated entities via an avidin functional intermediate. Continued development of this technology will allow for more accurate biomaterials-mediated mimicry of natural cells.