Nanoparticle Delivery of a Highly Toxic Metal Chelator to Cancer Cells

摘要

In summary, we present a promising approach to selectively deliver a highly toxic metal chelator, Dp44mT, to tumor cells using PLGA NPs. Our results show that the PLGA NPs can encapsulate Dp44mT with high efficiency and exhibit an improved solubility and a good stability in physiological solutions compared to the free drug. These NPs also showed a controlled release profile. Moreover, the proposed nanocarrier was able to maintain drug activity, enhance cellular uptake rate, and kill the cancer cells efficiently while sparing normal endothelial cells. Overall, the proposed formula may offer an attractive strategy for effective treatment of a number of solid tumors.