Composition and methods regarding the design and development of non-toxic and global anticancer drug that is achieved through organometallic nanoparticles with biologically active matals and enhanced permeation and retention effect

摘要

The present invention relates to a novel non-toxic and global anticancer drug employing nanoparticles that consist of a chelating organic polymer and biologically active metals, and enhanced permeation and retention (EPR) effect. More specifically, the present invention relates to water-soluble organometallic particles having anticancer effect via the EPR effect, comprising a multidentate metal chelating organic polymer and at least one metal moiety.