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Folate-conjugated molecules for delivery of toxic small molecule inhibitors to cancer cells and methods of use

机译:叶酸偶联分子,用于向癌细胞输送有毒的小分子抑制剂及其使用方法

摘要

The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and pharmaceutical preparations thereof. The invention further relates to methods of treating diseases such as cancer using the compounds of the invention.
机译:本发明涉及毒胡萝卜素的新型衍生物,其被靶向细胞表面表达受体的基团化学修饰,及其药物制剂。本发明进一步涉及使用本发明的化合物治疗疾病例如癌症的方法。

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