ASSEMBLY OF FILAMENTOUS TYPE 1 PILI FROM UROPATHOGENIC ESCHERICHIA COLI STRAINS

摘要

Understanding the assembly mechanism of supramolecular complexes and their molecular architecture at atomic resolution is one of the major challenges in biology. Despite the increasing number of solved three dimensional structures of large supramolecular assemblies and a large body of data on cellular factors required for their assembly in vivo, it is still extremely challenging to reconstitute supramolecular assemblies from all purified components in vitro and to obtain a complete picture of the assembly process that integrates structural, biochemical and in vivo data.