ANTI-IDIOTYPIC ANTIBODY AGAINST FIMH ADHESIN OF UROPATHOGENIC TYPE I-FIMBRIATED ESCHERICHIA COLI, COMPOSITIONS AND METHOD OF USE THEREOF

摘要

The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesion of uropathogenic Type I-fimbriated iEscherichia coli/i and an immunizing composition containing such an anti-idiotypic antibody or antigen-binding fragment thereof as an active immunizing component. The present invention also relates to a method for stimulating and enhancing the production of antibodies which recognize and bind to FimH of uropathogenic Type-I-fimbriated iEscherichia coli/i, but not to FimH of non-uropathogenic Type I-fimbriated iEscherichia coli/i.