Changes in the porcine peripheral blood mononuclear cell proteome induced by infection with highly virulent classical swine fever virus

摘要

@@Classical swine fever (CSF) is a highly contagious swine disease causing major losses in the pig industry. Its causative agent, classical swine fever virus (CSFV), a small enveloped RNA virus with a single stranded positive RNA genome, belongs to the genus Pestivirus within the family Flaviviridae. The virus is known to have a particular tropism for cells of the immune system and for endothelial cells, and monocytes both in peripheral blood and in the various lymphoid organs are its major targets. Thereby, the clinical symptoms and pathologic alterations of CSF are characterized by hemorrhagic fever and immunosuppression.