SYNTHESIS AND CHARACTERIZATION OF A NOVEL DENDRITIC MAGNETIC RESONANCE IMAGING CONTRAST AGENT

机译：新型树突磁共振成像造影剂的合成与表征

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A novel dendritic magnetic resonance imaging contrast agent based a new biodegradable dendrimer was synthesized and characterized by GPC and 1H NMR. Compared with small molecular MRI contrast agents, the dendritic contrast agents had significantly enhanced longitudinal ionic relaxivity (R1). The preliminary in vivo imaging experiments indicated that the dendritic contrast agents had long blood circulation time and kidney targeting ability.

机译：基于新的生物降解的树枝状聚合物的新型树突磁共振成像造影剂并通过GPC和1H NMR合成并表征。与小分子MRI造影剂相比，树突造影剂具有显着增强的纵向离子松弛率（R1）。体内成像实验的初步表明树突造影剂具有长期血液循环时间和肾靶向能力。

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《Symposium on innovative polymers for controlled delivery》|2010年||共3页
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Mingzhou Ye; Jianbin Tang; Xingping Wang; Jinxia Xu; Meihua Sui; Youqing Shen;
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中图分类生物材料学;
关键词
MRI contrast agent; dendrimer; biodegradable;

机译：MRI造影剂;树枝状;可生物降解;

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1. Synthesis and characterization of various benzyl diethylenetriaminepentaacetic acids (dtpa) and their paramagnetic complexes, potential contrast agents for magnetic resonance imaging [J] . Laurent S., Guerit N., Muller RN., Helvetica chimica acta . 2000,第2期

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2. Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent [J] . Tingting Li, Yue Qian, Mingzhou Ye, 中国化学（英文版） . 2014,第001期

机译：可生物降解的树枝状磁共振成像造影剂的合成与性能
3. Development of a Dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Contrast Agent: Synthesis, Toxicity (in Vitro) and Relaxivity (in Vitro, in Vivo) Studies [J] . Annabelle Benin, Jerome Steibel, Anne-Isabelle Michou-Gallani Bioconjugate Chemistry . 2009,第4期

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4. SYNTHESIS AND CHARACTERIZATION OF A NOVEL DENDRITIC MAGNETIC RESONANCE IMAGING CONTRAST AGENT [C] . Mingzhou Ye, Jianbin Tang, Xingping Wang, Symposium on innovative polymers for controlled delivery: Abstract book. . 2010

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SYNTHESIS AND CHARACTERIZATION OF A NOVEL DENDRITIC MAGNETIC RESONANCE IMAGING CONTRAST AGENT

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