SYNTHESIS AND CHARACTERIZATION OF A NOVEL DENDRITIC MAGNETIC RESONANCE IMAGING CONTRAST AGENT

机译：新型树枝状磁共振成像对比剂的合成与表征

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摘要

A novel dendritic magnetic resonance imaging contrast agent based a new biodegradable dendrimer was synthesized and characterized by GPC and 1H NMR. Compared with small molecular MRI contrast agents, the dendritic contrast agents had significantly enhanced longitudinal ionic relaxivity (R1). The preliminary in vivo imaging experiments indicated that the dendritic contrast agents had long blood circulation time and kidney targeting ability.

机译：合成了一种基于新型生物可降解树枝状聚合物的新型树枝状磁共振成像造影剂，并通过GPC和1H NMR对其进行了表征。与小分子MRI造影剂相比，树突状造影剂具有显着增强的纵向离子松弛度（R1）。初步的体内成像实验表明，树突状对比剂具有较长的血液循环时间和肾脏靶向能力。

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来源
《Symposium on innovative polymers for controlled delivery: Abstract book.》|2010年|p.576-578|共3页
会议地点 Suzhou(CN);Suzhou(CN)
作者
Mingzhou Ye; Jianbin Tang; Xingping Wang; Jinxia Xu; Meihua Sui; Youqing Shen;
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作者单位

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

Department of Chemical Biological Engineering, and Center of Bionanoengineering, Zhejiang University, Hangzhou 310027, China;

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原文格式 PDF
正文语种 eng
中图分类生物材料学;生物材料学;
关键词
MRI contrast agent; dendrimer; biodegradable;

机译：MRI造影剂；树状大分子；可生物降解;
入库时间 2022-08-26 14:20:03

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2. Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent [J] . Tingting Li, Yue Qian, Mingzhou Ye, 中国化学（英文版） . 2014,第001期

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SYNTHESIS AND CHARACTERIZATION OF A NOVEL DENDRITIC MAGNETIC RESONANCE IMAGING CONTRAST AGENT

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