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Development of Blood Mimicking Fluid Suspension using Polymer Particles

机译:使用聚合物颗粒的血液模拟血液悬浮液的发展

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Surgical simulation has become a key tool in the training of surgeons and improving patient safety. Presently, surgeons rehearse surgeries on 3D-printed anatomical models that are patient-specific, and water is used to represent blood. Unlike water, blood is a shear thinning fluid. Hence, it makes the simulation less realistic, as it lacks tactile feedback. This experimental study aims to develop a blood mimicking fluid (BMF) with micro-sized polymer particles to enhance realistic tissue handling and blood flow for surgical simulations. The polymer particles are meant to represent red blood cells in human whole blood. A range of 5 wt% to 55 wt% of polymer particles were added into BMF composing of 85 vol% water, 15 vol% glycerol and 0.03 wt% xanthan gum. The viscosities of the BMF samples were then measured against a range of shear rates, from 0.1 s~(-1) to 1000 s~(-1). The viscosity measurements were carried out at 25 °C, at 1 atm, which is at standard ambient temperature and pressure, similar to surgical simulation environment conditions. The viscosities of the BMF samples were validated using Power Law model and also compared with human whole blood. It was found that the asymptotic viscosity at high shear rates increases with the percentage of polymer particles. In spite of that, the BMF samples still portray shear-thinning properties.
机译:外科仿真已成为外科医生培训和改善患者安全的关键工具。目前,外科医生在患者特异性的3D印刷解剖模型上排练手术,水用于代表血液。与水不同,血液是剪切稀释液。因此,它使模拟更加逼真,因为它缺乏触觉反馈。该实验研究旨在开发具有微大型聚合物颗粒的血液模拟液(BMF),以增强外科模拟的现实组织处理和血流。聚合物颗粒旨在代表人类全血中的红细胞。将5wt%至55wt%的聚合物颗粒加入到85体积%的水,15体积%甘油和0.03wt%黄原胶中的BMF组成中。然后将BMF样品的粘度抵抗一系列剪切速率,从0.1s〜(-1)至1000 s〜(-1)。粘度测量在25℃下进行,在1个ATM处,其在标准环境温度和压力下,类似于手术模拟环境条件。使用电力法模型验证了BMF样品的粘度,也与人类全血相比。发现高剪切速率下的渐近粘度随比聚合物颗粒的百分比增加。尽管如此,BMF样品仍然描绘了剪切变薄性质。

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