Progress in Research on Protein Tyrosine Kinase Inhibitors

摘要

The occurrence and development of tumors are related to the disorder of intracellular signal transduction, especially the disorder of signal transduction pathway of receptor tyrosine kinase (RTK). Protein kinase inhibitors acting on this pathway can suppress the intracellular transmission of proliferation signals of tumor cells, thereby controlling their proliferation. Protein tyrosine kinase-mediated signal transduction pathway is currently an antitumor drug target which is studied by many researchers and demonstrates significant effects. Besides, as the main anti-tumor drug type available on market in recent years, multi-target tyrosine kinase inhibitors can inhibit multiple signal transduction pathways, induce the apoptosis of tumor cells, blocks the formation of new blood vessels, and inhibits the proliferation of tumor cells. Therefore, this paper reviews the relationship between tyrosine kinases and tumors, commercially available typical tyrosine kinase inhibitors, and their application prospects.