Effect of Water Cinnamon at A Dose of 150 mg/kg Body Weight to Level of Adiponectin on Diabetic Rats

摘要

Cinnamon is a member of the family Lauracea that is popular as an aromatic evergreen tree or shrub. In daily life cinnamon is used in fragrance of many things such as foodstuffs, perfumes, and medical products. Cinnamon contains polyphenols such as vanillic, gallic, protocatechuic, and ferulic acids, as well as eugenol that are dominantly found in its leaf. Cinnamon also contains antidiabetic, antibacterial, and antihemorrhagic agents. As antidiabetic agent, cinnamon decreases blood sugar in diabetic patients, but its effect on adiponectin is rare. This study was carried out to find out about the effect of steeping cinnamon on the adiponectin level indiabetic rats. Fifteen Sprague Dawley Rats were divided into three groups: normal, uncontrolled diabetic, and group treated by steeping cinnamon at a dose of 150mg/kg/day. Serum was collected during 14 days. Adiponectin was measured with ELISA method. The result of the study revealed that group I was used as the normal adiponectin values (733 ± 200 ng/mL to 763 ± 142.5 ng/mL). Adiponectin levels decreased in diabetic rats (group two) (p = 0.07). On the other hand, a group treated by steeping cinnamon at a dose of 150mg/kg/day showed an increased level of adiponectin (1.4% - 34.5%). To summarize, cinnamon water could increase the adiponectin level in diabetic rats.