Diclofenac as a factor in the change of Rhodococcus metabolism

摘要

The non-steroidal anti-inflammatory drug diclofenac (2-[2-(2,6-dichloroanilino)phenyl] acetic acid) is one of the most frequently detected pharmaceuticals in the environment. The ability of actinobacteria of the genus Rhodococcus to biodegrade diclofenac (170 μM) as the sodium salt has been revealed. Cells of R. ruber IEGM 231 pre-grown with diclofenac (1.7 μM) removed diclofenac (about 50% degradation) within 56 days in the presence of glucose. Diclofenac induced changes in the morphometric characteristics of rhodococci. The products of diclofenac biodegradation did not have pronounced phytotoxicity.