Cats presenting with signs of intracranial disease must be carefully considered when reviewing their history, signalment, physical examination and neurologic signs. Due to the greater emphasis placed on dogs in the neurology specialty, there is less awareness of some of the differentials for intracranial disease in the cat. Systemic diseases, such as hepatic encephalopathy, renal failure, electrolyte abnormalities, hyperadrenocorticism, hypoglycemia, hypertension and hyperthyroidism can cause signs of intracranial disease such as abnormal mentation, seizures, tremors and ataxia. Systemic causes of neurologic signs should be ruled out prior to the pursuit of advanced diagnostics such as magnetic resonance imaging and cerebrospinal fluid analysis.
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