The Effect Of Ipomoea reptans Poir Ethanolic Extract On The Histopathological Parameters Of Pancreas In Streptozotocin-Induced Diabetic Rats

摘要

The aim of this study was to investigate the effect of ethanolic extract of Ipomoea reptans Poir in male Wistar rats on the histopathological parameters of the pancreas. The rats (N=30) were divided into six groups, each consisting of five rats. The treatment groups were divided into: group I as the normal group fed ad libitum during the research, group II as the positive control administered glibenclamide 0.09 mg/200g BW, group III as the negative control given aquadest, and group IV to VI given ethanolic extract of Ipomoea reptans Poir as much as 200 mg/KgBW, 400 mg/KgBW and 600 mg/KgBW respectively. The study of antidiabetic effect was undertaken by oral administration for 21 days. On the 21st day, all the rats were dissected to prepare histopathological preparates through Gomori's chrome alum hematoxylinphloxine staining method. The histopathological study showed that the ethanol extract of Ipomoea reptans Poir at a dose of 200 mg/KgBW and 400mg/KgBW had an antidiabetic activity through protection of pancreatic β-cell from damage in male Wistar rats induced by streptozotocin.