Combination of carboxymethyl cellulose (CMC) - Corn starch edible film and glycerol plasticizer as a delivery system of diclofenac sodium

摘要

The drug delivery system is a system given in a single dose to deliver the drug as early as possible, provide pharmacological effects for as long as possible, and deliver the drug directly to the workplace (target) safely. One method of drug delivery system is with edible film. One of the materials that can be utilized in making edible film is the combination of Carboxymethyl Cellulose (CMC) and corn starch. The drug used in this study was diclofenac sodium. This research aims to study the mechanical characteristics of drug-contained edible film, swelling value, and comparison of research results with standard edible film. The research method consisted of two variations: (1) making edible film with composition of CMC-corn starch polymer (4:0, 3:1, 2:2, and 1:3) dipped in CaCl_2.2H_2O solution containing of glycerol and diclofenac sodium, and (2) making edible film with glycerol (0%, 5%, 10%, 15%, and 20%) on the most optimal polymer from previous variation. The measured mechanical characteristics of edible films are thickness, tensile strength and elongation. The results show that the addition of corn starch and glycerol have an effect on the characteristic of edible film. The addition of corn starch (0-3 gram) and glycerol (0-20%) leads to the declining value of the film's tensile strength and the increasing percentage elongation. The highest tensile strength and the highest percentage elongation was obtained by polymer with composition of CMC-corn starch of 4: 0 and the concentration of glycerol of 20%. The addition of diclofenac sodium in edible film still provides suitable compared to the control and the results prove that edible film can be used as drug delivery system.