The Enzyme-mimic Activity of Maltodextrin Stabilized Cerium Dioxide Nanoparticles

摘要

In recent years cerium dioxide nanoparticles (CDNPs) has received increasing attention due to their ability to act as enzymes in the living organisms. Their biological activity is determined by the presence of mixed valence states and oxygen vacancies on the nanoparticles surface. Therefore, the physicochemical properties of the surface are the key element influencing the activity of nanoparticles in biological systems. The use of various stabilizers in the nanoparticles synthesis can lead to the modification of the surface properties and, as a consequence, to the change or complete loss of nanoparticles activity. Therefore, an important problem in the synthesis of nanoparticles for medical use is the choice of a stabilizer, which would be biocompatible and non-toxic and at the same time, all the properties of nanoparticles would be remained. This work is devoted to the study of the maltodextrin stabilized CeO_(2-x) nanoparticles by optical spectroscopy. The enzyme-mimic activity of nanoparticles was considered in terms of their ability to mimic the behavior of catalase. The catalase-like properties of CeO_(2-x) nanoparticles was investigated by analyzing changes in the optical spectra caused by their interaction with hydrogen peroxide. The influence of medium properties on the nanoparticles activity was also studied. The results of the study show the ability of CeO_(2-x) nanoparticles to act like catalase, as well as the dependence of their catalase-mimicing activity on the pH medium.