Antibacterial Properties of Copper Nanoparticle Dispersions: Influence of Synthesis Conditions and Physicochemical Characteristics

摘要

The production of bactericidal plasters, bandages and medicines with the inclusion of copper nanoparticles and copper ions may have a great potential in terms of their biomedical application. The work considers the influence of the synthesis conditions, size, aggregation status, and charge of nanoparticles in aqueous solutions as well as the type of microorganisms to the antibacterial properties of water suspensions of electroexplosive copper nanoparticles in the conditions in vitro in relation to strains Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus. Water dispersions of copper nanoparticles were shown to inhibit the growth of test cells for-both G+ and G- microbacteria but the degree of such an influence strongly depended on the type of a test strain. The authors have demonstrated that use of deeply purified water and alcohol-containing stabilizers at the synthesis of nanoparticles via metals electric erosion in the liquid prevents the copper nanoparticles coagulation and significantly influences on their physicochemical characteristics and, consequently, antibacterial properties.