Codonopsis on Exercise Stress Ulcer rat stomach tissues and motilin content on HSP70 expression

摘要

Objective: To investigate the occurrence of exercise stress gastric ulcer during motilin hormone content and expression of HSP70 and dangshen on Exercise Stress Ulcer Prevention effect and its mechanism. Methods: 30 adult SD rats were divided into three groups, each 10, divided into the control group, movement control, movement dosing group, the establishment of Exercise Stress Gastric Ulcer Model. Each group of rats gastric mucosa pathological damage index scoring by immunohistochemical staining gastric mucosa HSP70 expression; gastric tissue content preparation, testing motilin. Results: Compared with quiet group, gastric motility group organization motilin levels were significantly increased, slightly increased HSP70 expression; compared with motion control, dosing rats gastric tissue motilin levels were significantly decline, HSP70 expression increased further. Conclusion: Codonopsis can prevent exercise stress gastric ulcer, the protective mechanism may reduce gastric tissue in rats motilin content and increase the expression of HSP70 related. All organisms under stress conditions can be synthesized in a highly conserved protective protein that is HSPs, especially high-intensity sports exhaustive exercise as a source of stress, causing physiological functions of various organ systems of the human body changes over the past decade, people express when the body motion stress HSPs conducted experimental studies, have found that the expression of HSPs[1] in the brain, liver, heart, skeletal muscle, spleen and blood cells and other parts of the body after exercise, HSP70 family is the most important one of its kind HSP protect the gastric mucosa, but there are no studies on exercise and stomach tissues of HSP70 relations. Numerous studies show that high intensity exhaustive exercise, especially as a strong source of stress, the blood flow to reduce the gastrointestinal tract, increased production of free radicals, lipid peroxidation increased production, will eventually cause gastric mucosal protective effect and injury of loss of balance, causing Exercise Stress Ulcer[2]. Clinical studies have shown dangshen, spleen, stomach, regulate gastrointestinal function, antioxidant and immunomodulatory effects[3]. Expression and motilin content in this experiment study the role of HSP70 in gastric stress ulcer in sport and in prevention of Codonopsis.