Evaluation of PCL/GE-based Electrospun Nanofibers for Tissue Engineering and Drug Delivery Application

摘要

Scaffold provides a suitable medium for cell growing and drug delivery while enhancing the cell transplantation efficiency. In this project, nanofibrous scaffolds were fabricated through electrospinning of Polycaprolactone (PCL) and Gelatin (GE). Processing parameters and solution parameters were optimized to achieve the desired properties of PCL/GE nanofibers. Scanning Electron Microscopy (SEM), water contact angle and Attenuated Total Reflectance-Fourier Transformed Infrared Spectroscopy (ATR-FTIR) were implemented to characterize the fabricated nanofibers. It was found that 14% w/v PCL/GE shows the best fibers' diameter, pore size, contact angle and less bead formation. This sample is suitable to be further investigated for the application of tissue engineering (TE) and drug delivery system (DDS).