Most seizures in dogs are self-limiting and last a couple 01 minutes or less. Seizures that last more than a lew minutes or occur back-to-back without recovery in-between are emergency situations and should be treated promptly, aggressively, and witha systematic plan.1 When 30-60 minutes of continuous seizure activity occurs, irreversible neuronal damage begins, mainly due to excito-toxic cell injury related to excessive glutamate release.2 This can lead to loss of normal brain homeostasis, kindling, functional and structural hippocampal changes, neuro-degeneration and altered distribution of ion channels and neurotransmitter receptors on a cellular level.3 Systemically, status epilepticus (SE) can result in hyperglycemia, hypertension,4 neuronal necrosis, hyperthermia, cardiac arrhythmias, kidney damage, metabolic acidosis, disseminated intravascular coagulation, cardiorespiratory failure, and a predisposition to further seizure episodes.5 Consequently, aggressive and safe early intervention is important. This review will cover old drugs and also drugs *new* or "potentially new*" for canine SE.
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