The correlation studies about histone modification and H2A. Z nucleosome positioning

摘要

In eukaryotes chromatin, H2A. Z is highly conservative histone variants and closely associated with transcriptional regulation and the stability of the genome. In order to explore the link between histone modification data, and H2A.Z nucleosome positioning data, we discussed the linear or nonlinear relationships between those data around the transcription start site in the yeast genome-wide by MIC algorithm. The results showed there are two kinds of histone modification data (H4ac and GCN4)existed in an undiscovered nonlinear relationship with nucleosone position and discussed the reasons from biological sense.