Silver nanoislands based SERS-active substrates for DNAs detection

摘要

Surface enhanced Raman spectroscopy (SERS) based on plasmonic colocalization between DNA attached gold nanoparticles and silver nanoislands substrates. Raman spectra measured on a silver nanoislands substrate were observed 20 and 1.8 folds signal enhancements relative to them on a film substrate with high and low numerical apertures of lenses, respectively. By comparison between calculations and experiments results, we proved that distinct differences of the signal enhancements came from changing field of view on random nanoislands substrate. Consequently, we show that nanoislands substrates with a precise position control can be a good candidate for a SERS substrate which can achieve significant signal enhancements without a complicated lithographic process.