A Potential Anti-schistosomal Agent Containing 1,2,5-Oxadiazole-2-oxide and Praziquante Moieties

摘要

3-Praziquantel-4-(4-chlorophenylsulfonyl)-1, 2, 5-oxadiazol-2-oxide was synthesized via the coupling reaction of praziquante and 1, 2, 5-oxadiazole in ethylene glycol, and its molecular structure was confirmed by the melting point and spectroscopic data (UV, IR, and ~1H NMR). Moreover, it may be a potential anti-schistosmal agent.