The impact of laser radiation on the photodissociation of carboxyhemoglobin in blood

摘要

This paper presents an experimental study in vivo of the rate of the carboxyhemoglobin (HbCO) photodissociation in blood under the influence of the transcutaneous laser irradiation in visible spectral range from 405 to 700 nm. Despite the similarity of the HbCO and HbO_2 action spectra, the designed 3-wavelengths measurement system makes it possible to obtain reliable measuring of the HbCO decrease level. The results show that there is a relatively narrow spectral range in the visible region where one could effectively (up to 50%) dissociate carboxyhemoglobin in blood through the tissue. The obtained results can be used in clinical practice on phototherapy and for effective treatment of CO poisoning.