Chapter 22 Study of Nanocomposites of Amino Acids and Organic Polyethers by Means of Mass Spectrometry and Molecular Dynamics Simulation

摘要

Nanocomposites made of biomolecules and organic components are promising for biomedical and pharmaceutical applications [1], drug delivery in particular [2]. Organic nanoparticles composed of proteins and polyether polymers are currently under development [2]. Knowledge on parameters of intermolecular interactions of proteins with polyethers is necessary for elaboration of advanced materials and technological procedures. The complexity and heterogeneity of such systems, however, hampers obtaining information on their structure. In this connection, socalled monomeric approximation in which interactions of the building blocks of macromolecules are modeled may be helpful.