Measurement of High-Molecular-Weight Adiponectin is not Useful in Assessing Coronary Stenosis in Japanese Male

摘要

In many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated. We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin levels and coronary stenosis in 83 male patients and 138 male controls.There were no significantly differences between cases and controls in HMW adiponectin levels. From receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin levels. (Total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin levels and coronary stenosis.